Caring for cancer patients is my passion and inspiration as a physician. I strive to make clinical trials available to all patients because clinical trials are the only path to finding a cure, and because - where there is life there is hope.
Medical Oncologist, Virginia Cancer Specialists Research Institute
Medical Oncology, Hematology and Internal Medicine
Advanced Developmental Therapeutics, National Cancer Institute, National Institutes of Health Hematology and Oncology, University of Cincinnati
Saint Louis University School of Medicine
University of Damascus School of Medicine, Damascus, Syria
Clinical Trials
Mohamad Adham Salkeni, MD, FRCPC earned his medical degree from the University of Damascus. He then completed his residency in internal medicine at St. Louis University and fellowship in hematology and oncology at the University of Cincinnati. During his medical training, he was engaged in bench and translational research investigating inflammatory modulation of the blood-brain barrier in vivo, published in the Journal of Neuroimmune Pharmacology; and established a tumor-informed assay for detecting circulating mutant DNA of brain cancer, published in the Journal of Neuro-Oncology. Following training completion, he joined West Virginia University as an Assistant Professor and was later promoted to Associate Professor, where he also served as Medical Director for the Clinical Trials Research Unit and Co-Chair of the Breast Cancer Leadership Committee. Interested in early drug development, Dr. Salkeni elected to move on to the National Cancer Institute, National Institutes of Health (NCI/NIH) in Bethesda, Maryland, where he completed a fellowship in Advanced Developmental Therapeutics. During his time spent at the NCI, he participated in concept development and design of early phase clinical trials of novel immunotherapeutics and small molecules, and authored a book chapter on resistance mechanisms to immunotherapy.
Dr. Salkeni is a member of the American Society of Clinical Oncology (ASCO), American Association for Cancer Research (AACR), American Society of Hematology (ASH), and the Society for Immunotherapy of Cancer (SITC). Dr. Salkeni joined Virginia Cancer Specialists as a Clinical Investigator in Phase 1 cancer clinical trials, in collaboration with NEXT Oncology.
In his spare time, he enjoys swimming and spending time outdoors with family.
Abstract CT115: Safety and efficacy of Anti-PD-L1 antibody MEDI4736 (durvalumab) in combination with capecitabine in patients with advanced solid tumors (DURVA+)
Read MoreA phase 2 study of anti-PD-L1 antibody (atezolizumab) in grade 2 and 3 chondrosarcoma.
Read MoreResistance to Immunotherapy: Mechanisms and Means for Overcoming
Read MoreAbstract P049: Phase II trial of TRC102 (methoxyamine HCl) in combination with temozolomide (TMZ) in patients with advanced non-small cell lung cancer
Read MorePhase II trial of TRC102 (methoxyamine HCl) in combination with temozolomide (TMZ) in patients with advanced non-small cell lung cancer
Read MoreGuest Editor and Reviewer Acknowledgments: 2021
Read MoreNeu Perspectives, Therapies, and Challenges for Metastatic HER2-Positive Breast Cancer
Read MoreSapanisertib Plus Exemestane or Fulvestrant in Women with Hormone Receptor-Positive/HER2-Negative Advanced or Metastatic Breast Cancer
Read MoreResistance to Immunotherapy: Mechanisms and Means for Overcoming
Read MoreResistance to Immunotherapy: Mechanisms and Means for Overcoming
Read MoreGuest Editor and Reviewer Acknowledgments: 2020
Read MoreSafety and Efficacy of T-DM1 Plus Neratinib in Patients With Metastatic HER2-Positive Breast Cancer: NSABP Foundation Trial FB-10
Read MoreUnderstanding palbociclib practice patterns in a real-world setting.
Read MoreNEDD9 adaptor protein regulates HER2-driven metastasis in breast cancer
Read MoreThe Stem Cell Phenotype of Aggressive Breast Cancer Cells
Read MoreAbstract PD1-09: Phase 2 safety and efficacy results of TAK-228 in combination with exemestane or fulvestrant in postmenopausal women with ER-positive/HER2-negative metastatic breast cancer previously treated with everolimus
Read MoreAnalysis of ERBB2 (HER2) amplification by ctDNA in a phase Ib dose-escalation trial evaluating trastuzumab emtansine (T-DM1) with neratinib in women with metastatic disease
Read MoreTime to treatment discontinuation of second-line fulvestrant monotherapy for HR+/HER2-metastatic breast cancer in the real-world setting
Read MoreSwitching endocrine therapy in breast cancer as a strategy for musculoskeletal symptoms, tolerance, and adherence.
Read MoreFirst report of real-world patient characteristics and treatment patterns from POLARIS: Palbociclib in hormone receptor-positive (HR+) advanced breast cancer: A prospective, multicenter, noninterventional study
Read MorePrognostic factors in breast cancer patients evaluated by positron-emission tomography/computed tomography before neoadjuvant chemotherapy
Read MoreNSABP FB-10: Phase Ib dose-escalation trial evaluating trastuzumab emtansine (T-DM1) with neratinib (N) in women with metastatic HER2+ breast cancer (MBC).
Read MoreMetastatic breast cancer: Endocrine therapy landscape reshaped
Read MoreA Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies
Read MorePrognostic factors in breast cancer patients evaluated by PET/CT prior to neoadjuvant chemotherapy.
Read MoreRetrospective analysis of the role of CA 15-3 as a biomarker for breast cancer relapse.
Read MoreA Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies
Read MoreRandomized Phase II Study of Ramucirumab or Icrucumab in Combination with Capecitabine in Patients with Previously Treated Locally Advanced or Metastatic Breast Cancer
Read MorePhase 1b/2 safety and efficacy of TAK-228 (MLN0128), plus exemestane (E) or fulvestrant (F) in postmenopausal women with ER + /HER2- metastatic breast cancer (MBC)
Read MoreAbstract B20: Development of metastatic patient-derived xenografts (PDXs) for accurate assessment of anti-metastatic therapeutics in pre-clinical settings
Read MoreCombination of Eribulin and Aurora A Inhibitor MLN8237 Prevents Metastatic Colonization and Induces Cytotoxic Autophagy in Breast Cancer
Read MoreLongitudinal study of arm impairments, function and quality of life following mastectomy.
Read MoreKruppel-like Pluripotency Factors as Modulators of Cancer Cell Therapeutic Responses
Read MoreKruppel-like Pluripotency Factors as Modulators of Cancer Cell Therapeutic Responses
Read MoreResolution of Telangiectasia Macularis Eruptiva Perstans with successful treatment of synchronous large granular lymphocytic leukemia
Read MoreOptimal management of sentinel lymph node positive biopsy patients in early breast cancer
Read MoreRegulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer
Read MoreP1.14 - A Dose Escalation Single Arm Phase Ib Combination Study of BEZ235 with Everolimus in Patients with Advanced Solid Malignancies
Read MoreAbstract PD3-04: Analysis of ERBB2 (HER2) amplification by ctDNA in a phase Ib dose-escalation trial evaluating trastuzumab emtansine (T-DM1) with neratinib in women with metastatic disease with initially diagnosed HER2+ breast cancer: NSABP FB-10
Read MoreMicroRNAs 206 and 21 cooperate to promote RAS-extracellular signal-regulated kinase signaling by suppressing the translation of RASA1 and SPRED1
Read MoreMicroRNAs 206 and 21 Cooperate To Promote RAS–Extracellular Signal-Regulated Kinase Signaling by Suppressing the Translation of RASA1 and SPRED1
Read MoreDetection of EGFRvIII mutant DNA in the peripheral blood of brain tumor patients
Read MoreDetection of EGFRvIII mutant DNA in the peripheral blood of brain tumor patients
Read MorePatient selection for anti-EGFViii therapies in glioblastoma multiforme (GBM): Use of circulating tumor DNA.
Read MoreBEZ235 in combination with everolimus for advanced solid malignancies: Preliminary results of a phase Ib dose-escalation study.
Read MoreBevacizumab and Glioblastoma Multiforme: A Thrombosis and Bleeding Dilemma (A Case Report and a Brief Review of the Literature).
Read MorePatient Selection for Anti-Egfviii Therapies in Glioblastoma Multiforme (GBM): Use of Circulating Tumor DNA
Read MoreIdentification of a new mutation in the EGFR ligand-binding domain: Predictive factor for cetuximab antitumor activity in head and neck carcinoma?
Read MoreA dose escalation, single arm, phase Ib/II combination study of BEZ235 with everolimus to determine the safety, pharmacodynamics, and pharmacokinetics in subjects with advanced solid malignancies including glioblastoma multiforme.
Read MoreLipopolysaccharide impairs blood-brain barrier P-glycoprotein function in mice through prostaglandin- and nitric oxide-independent pathways
Read MoreLipopolysaccharide Impairs Blood–Brain Barrier P-glycoprotein Function in Mice Through Prostaglandin- and Nitric Oxide-Independent Pathways
Read MoreA Phase 1b/2, Dose-escalation, Randomized, Multicenter Study of Maintenance Ivaltinostat plus Capecitabine or Capecitabine Monotherapy in Patients with Metastatic Pancreatic Adenocarcinoma Whose Disease Has Not Progressed on First Line FOLFIRINOX Chemotherapy
"A PHASE II RANDOMIZED, OPEN-LABEL, TRIAL OF NAB-PACLITAXEL + GEMCITABINE WITH OR WITHOUT BOTENSILIMAB (AGEN1181) IN PATIENTS WITH METASTATIC PANCREATIC CANCER WHO HAVE PROGRESSED ON PRIOR 5FU + LEUCOVORIN + IRINOTECAN + OXALIPLATIN (FOLFIRINOX)"
Phase I/II First-in-Human Study of TT-10 as a Single Agent in Subjects With Advanced Selected Solid Tumors
A Phase 1 Open-Label, Multi-Center, Safety and Efficacy Study of PRT3645 in Participants With Select Advanced or Metastatic Solid Tumors
A Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics/Pharmacodynamics, and Antitumor Activity of NM1F as Monotherapy and in Combination With Pembrolizumab in Subjects With Locally Advanced/Metastatic Solid Tumors
A Phase 1/2a, Open-Label, Multicenter, Nonrandomized, Safety and Anti-tumor Activity Study of IMM-1-104, a Novel Oral Dual MEK1/2 Inhibitor in Participants With Previously Treated RAS-Mutated Advanced or Metastatic Solid Tumors
A Phase 1b/2, Dose-escalation, Randomized, Multicenter Study of Maintenance Ivaltinostat plus Capecitabine or Capecitabine Monotherapy in Patients with Metastatic Pancreatic Adenocarcinoma Whose Disease Has Not Progressed on First Line FOLFIRINOX Chemotherapy
“A PHASE II RANDOMIZED, OPEN-LABEL, TRIAL OF NAB-PACLITAXEL +
GEMCITABINE WITH OR WITHOUT BOTENSILIMAB (AGEN1181) IN PATIENTS
WITH METASTATIC PANCREATIC CANCER WHO HAVE PROGRESSED ON
PRIOR 5FU + LEUCOVORIN + IRINOTECAN + OXALIPLATIN (FOLFIRINOX)”
Phase I/II First-in-Human Study of TT-10 as a Single Agent in Subjects With Advanced Selected Solid Tumors
A Phase 1 Open-Label, Multi-Center, Safety and Efficacy Study of PRT3645 in Participants With Select Advanced or Metastatic Solid Tumors
A Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics/Pharmacodynamics, and Antitumor Activity of NM1F as Monotherapy and in Combination With Pembrolizumab in Subjects With Locally Advanced/Metastatic Solid Tumors
A Phase 1/2a, Open-Label, Multicenter, Nonrandomized, Safety and Anti-tumor Activity Study of IMM-1-104, a Novel Oral Dual MEK1/2 Inhibitor in Participants With Previously Treated RAS-Mutated Advanced or Metastatic Solid Tumors
A Dose Escalation Study of HFB301001 (OX40 Agonist Antibody) in Adult Patients With Advanced Solid Tumors
A Phase 1, 2-Part, Multicenter, First-In-Human Dose-Escalation and Dose-Expansion Study of DS-1103a Combination Therapy in Subjects With Advanced Solid Tumors
NCT05765851
A Phase 1 Study of the SHP2 Inhibitor BBP-398 (Formerly Known as IACS-15509) in Combination With the Programmed Death Receptor-1 Blocking Antibody Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer With a KRAS Mutation
A Phase 1 First in Human Study Evaluating Safety, Pharmacokinetics and Efficacy of ABBV-400 in Adult Subjects With Advanced Solid Tumors