An orally available, stable formulation comprised of sulforaphane, a naturally-occurring phytochemical belonging to the class of isothiocyanates, and encapsulated within alpha-cyclodextrin, with cancer preventive activity. Upon administration, sulforaphane acts as an antioxidant and potent stimulator of endogenous detoxifying enzymes. This agent is able to induce phase II detoxification enzymes, such as glutathione S-transferase and quinone reductase, thereby providing protection against certain carcinogens and toxins. Broccoli sprouts contain large amounts of sulforaphane, which is also found in other cruciferous vegetables including cabbage and kale. Cyclodextrin is able to prevent sulforaphane’s rapid breakdown, which improves its stability and half-life. Check for active clinical trials using this agent. (NCI Thesaurus)
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