An iodinated doxorubicin analogue with antiamyloid activity. 4′-Iodo-4′-deoxydoxorubicin (IDOX) binds with high affinity to five types of natural amyloid fibrils including immunoglobulin light chains, amyloid A, transthyretin (methionine-30 variant), -protein (Alzheimer), and 2-microglobulin. This agent may inhibit fibril growth, increasing the solubility of amyloid tissue deposits and facilitating their clearance. IDOX has also been shown to insulin amyloid fibrillogenesis in vitro. Check for active clinical trials using this agent. (NCI Thesaurus)
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