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A synthetic fluoro derivative of thiacytidine with potent antiviral activity. Emtricitabine is phosphorylated to form emtricitabine 5′-triphosphate within the cell. This metabolite inhibits the activity of human immunodeficiency virus (HIV) reverse transcriptase both by competing with the natural substrate deoxycytidine 5′-triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack of the essential 3′-OH group). Check for active clinical trials using this agent. (NCI Thesaurus)
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