Attention Gainesville Patients: With the LPGA Solheim Cup 2024 coming to the Robert Trent Jones Golf Club in Gainesville, Sept 10-15, please be advised that significant traffic and potential delays are expected in the area. We encourage you to plan your outings accordingly, leaving extra time for travel. Thank you.
An orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. As a specific retinoic acid receptor (RAR) alpha/beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL-60 (human promyelocytic leukemia) cell lines in vitro. Due to a lower affinity for cellular retinoic acid binding protein (CRABP), tamibarotene may show sustained plasma levels compared to ATRA.In addition, this agent may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium. Check for active clinical trials using this agent. (NCI Thesaurus)
Related Posts
Recent Posts
