A nucleoside analog. Pyrazofurin potently inhibits orotidine 5′-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. Check for active clinical trials using this agent. (NCI Thesaurus)

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