ALERT: Practice Announcement 2/7/25 – Our practice is actively monitoring the weather for the coming week. Please stay tuned to our website for the latest announcements or closures.      Exciting News! Our Gainesville Office has moved to Bristow9450 Innovation Drive, Manassas, VA 20110.  Same great providers and care team, same exceptional care, new, larger space to better serve our patients.

pexastimogene-devacirepvec

A thymidine kinase-deleted vaccinia virus expressing human GM-CSF (hGM-CSF) with oncolytic activity. Upon intratumoral or intravenous administration, pexastimogene-devacirepvec may selectively infect and lyse tumor cells. While vaccinia displays a natural tumor cell tropism, deletion of the thymidine kinase gene increases the tumor selectivity of vaccinia by limiting viral replication to transformed cells. hGM-CSF expression by this agent may help recruit antigen processing cells (APCs), such as denritic cells and macrophages, to virally infected tumor cells, initiating a systemic antitumoral immune response. Check for active clinical trials using this agent. (NCI Thesaurus)

Related Posts

Award Winning Physicians

Our Physicians work for you, ensuring the highest standard of care.

Learn More