Important Notice: Normal Operations Despite Inclement Weather. Due to current weather conditions, we want to assure all patients that there are no delays in our services. We are continuing with normal operations and remain fully committed to providing the care you need. Please proceed with your scheduled appointments as planned. Stay safe! Exciting News! Our Gainesville Office has moved to Bristow – 9450 Innovation Drive, Manassas, VA 20110. Same great providers and care team, same exceptional care, new, larger space to better serve our patients.
A histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. CG200745 inhibits the catalytic activity of HDAC, resulting in an accumulation of highly acetylated chromatin histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. In particular, this agent enhances the histone acetylation of the tumor suppressor gene p53. This results in an accumulation of p53, p53-dependent transactivation and apoptosis in tumor cells. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Check for active clinical trials using this agent. (NCI Thesaurus)
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