Important Notice: Normal Operations Despite Inclement Weather. Due to current weather conditions, we want to assure all patients that there are no delays in our services. We are continuing with normal operations and remain fully committed to providing the care you need. Please proceed with your scheduled appointments as planned. Stay safe! Exciting News! Our Gainesville Office has moved to Bristow – 9450 Innovation Drive, Manassas, VA 20110. Same great providers and care team, same exceptional care, new, larger space to better serve our patients.
The hydrochloride salt of the synthetic high-affinity transition-state analogue forodesine. Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction. Check for active clinical trials using this agent. (NCI Thesaurus)
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