Attention Gainesville Patients: With the LPGA Solheim Cup 2024 coming to the Robert Trent Jones Golf Club in Gainesville, Sept 10-15, please be advised that significant traffic and potential delays are expected in the area. We encourage you to plan your outings accordingly, leaving extra time for travel. Thank you.
A human IgG1 monoclonal antibody directed against neuropilin-1 (NRP1), with potential antiangiogenic and antineoplastic activities. Upon intravenous administration, MNRP1685A specifically targets and binds to NRP1; the antibody-NRP1 complex prevents the subsequent coupling of NRP1 to VEGFR2, thereby potentially inhibiting VEGF-mediated signaling and potentially preventing angiogenesis. In combination with other anti-VEGF therapies, MNRP1685A may enhance their anti-angiogenic effect. NRP1 is a membrane-bound co-receptor normally expressed by endothelial cells and overexpressed by certain tumor cells, and plays a role in angiogenesis, cell survival, migration, and invasion. Check for active clinical trials using this agent. (NCI Thesaurus)
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