3'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine

A hapten-carrier immunoconjugate composed of the hapten trans-3-aminomethyl nicotine conjugated to a recombinant P. aeruginosa exoprotein A, rendered nontoxic through amino acid depletion, with potential immunostimulating activity. Upon vaccination with 3′-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine, the immune system may produce anti-nicotine antibodies. Antibody-bound nicotine cannot pass the blood brain barrier (BBB) to activate brain nicotine receptors. Nicotine, a small organic molecule that is notimmunogenic, must be haptenized and conjugated to a carrierprotein, such as nontoxic recombinant P. aeruginosa exoprotein A, to induce an antibody response. Aluminiumhydroxide may be used as an adjuvant for this vaccine. Check for active clinical trials using this agent. (NCI Thesaurus)

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